Abstract There is accumulating evidence of endothelial dysfunction. muscle and cerebral hypoperfusion in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). In this paper we deduce the pathomechanisms resulting in central nervous pathology and the myriad of neurocognitive symptoms. We outline tentative mechanisms of impaired cerebral blood flow. https://www.markymarkscott.com/product-category/remarkable-silkness-lightness-and-shine/